The importance of the position of the carbonyl group is evident when we consider 2-butanone: here, the protons on C 1 and C 3 are somewhat acidic (in the neighborhood of pK a = 19), but the protons on...The importance of the position of the carbonyl group is evident when we consider 2-butanone: here, the protons on C 1 and C 3 are somewhat acidic (in the neighborhood of pK a = 19), but the protons on C 4 are not acidic at all, because C 4 is not adjacent to the carbonyl.
