A critical element in the three-dimensional structure of any enzyme is the presence of an ‘active site’, which is a pocket, usually located in the interior of the protein, that serves as a docking poi...A critical element in the three-dimensional structure of any enzyme is the presence of an ‘active site’, which is a pocket, usually located in the interior of the protein, that serves as a docking point for the enzyme’s substrate(s) (‘substrate’ is the term that biochemists use for a reactant molecule in an enzyme-catalyzed reaction).