The Grignard reagent is a very strong base, so the same precautions that were discussed above for alkynyl carbanions must be taken to avoid contact with water or anything that is even slightly acidic ...The Grignard reagent is a very strong base, so the same precautions that were discussed above for alkynyl carbanions must be taken to avoid contact with water or anything that is even slightly acidic (in the syntheses above, acid is added only as the final step in order to recover protonated product and also to inactivate any remaining Grignard reagent).