First, a series of three reactions is required to introduce the necessary ketone group to the beta position (two of these reactions are oxidative, and will be discussed in chapter 16; the third is som...First, a series of three reactions is required to introduce the necessary ketone group to the beta position (two of these reactions are oxidative, and will be discussed in chapter 16; the third is something that we will see in chapter 14). In the following example (a reaction in the biosynthesis of the antibiotic indolmycin) the nucleophile is the alpha-carbon of an enol intermediate.
