A reaction in the histidine biosynthetic pathway provides a good example of a biological E1-like elimination step (we're looking specifically here at the first, enol-forming step in the reaction below...A reaction in the histidine biosynthetic pathway provides a good example of a biological E1-like elimination step (we're looking specifically here at the first, enol-forming step in the reaction below - the second step is simply a tautomerization from the enol to the ketone product (section 13.1A)).